scholarly journals Multiple myeloma associated with immune thrombocytopenic purpura

Cancer ◽  
1985 ◽  
Vol 56 (5) ◽  
pp. 1199-1200 ◽  
Author(s):  
Joseph D. Verdirame ◽  
John R. Feagler ◽  
James R. Commers
Keyword(s):  
Multiple Myeloma ◽  
Immune Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

scholarly journals Lenalidomide-Associated ITP

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Christina I. Herold ◽  
Cristina Gasparetto ◽  
Gowthami M. Arepally
Keyword(s):  
Multiple Myeloma ◽  
Immune Thrombocytopenic Purpura ◽  
Hematologic Malignancies ◽  
Thrombocytopenic Purpura ◽  
Immunomodulatory Agent ◽  
The Common ◽  
Immunomodulatory Properties

Lenalidomide is a potent immunomodulatory agent being used increasingly for treatment of hematologic malignancies including multiple myeloma and myelodysplasia. The common toxicities of lenalidomide, including dose-limiting myelosuppression, are well described. However, the immunomodulatory properties of lenalidomide may give rise to unexpected autoimmune complications. Herein, we describe a case of immune thrombocytopenic purpura (ITP) associated with use of lenalidomide.

scholarly journals ITP revealing a SMM: A case report and review of the literature

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Rim Rakez ◽  
◽  
Areej Chefaii ◽  
Rym Hadhri ◽  
Mouna Bahrini Sassi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Immune Thrombocytopenic Purpura ◽  
Autoimmune Disorder ◽  
Causal Link ◽  
Lymphoproliferative Disorders ◽  
Review Of The Literature ◽  
Platelet Response ◽  
Thrombocytopenic Purpura ◽  
Smoldering Multiple Myeloma ◽  
Plasma Cell Neoplasms

Immune thrombocytopenic purpura is an autoimmune disorder retained after elimination of other causes of low platelets’ rate. It is mostly seen with B cell lymphoproliferative disorders. Immune thrombocytopenic purpura’s association with plasma cell neoplasms is possible but extremely rare. Although several pathophysiological mechanisms have been proposed, the causal link between these two conditions is not yet clearly understood. Therapeutic management is not standardized and depends mainly on the type of gammopathy and the chronology of onset of immune thrombocytopenic purpura compared to multiple myeloma. Our case is about an 81-year-old male diagnosed with concurrent smoldering multiple myeloma and immune thrombocytopenic purpura who was started on steroids without anti-neoplastic therapy for multiple myeloma with partial platelet response. We also review the few reported cases of simultanious immune thrombocytopenic purpura and smoldering multiple myelom or multiple myeloma. Keywords: ITP; thrombocytopenia; smoldering multiple myeloma; corticosteroids.

scholarly journals Multiple myeloma with concurrent immune thrombocytopenic purpura

2020 ◽  
Vol 14 ◽  
Author(s):  
Humaira Sarfraz ◽  
Kartik Anand ◽  
Shujuan Liu ◽  
Shilpan Shah
Keyword(s):  
Multiple Myeloma ◽  
Immune Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

Successful management of immune thrombocytopenic purpura with thalidomide in a patient with multiple myeloma

2004 ◽  
Vol 5 (5) ◽  
pp. 456-457 ◽  
Author(s):  
Patrizia Falco ◽  
Alessandra Bertola ◽  
Sara Bringhen ◽  
Federica Cavallo ◽  
Mario Boccadoro ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Immune Thrombocytopenic Purpura ◽  
Successful Management ◽  
Thrombocytopenic Purpura

scholarly journals Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn’s Disease: Case Vignette and Systematic Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Raisa Epistola ◽  
Tiffanie Do ◽  
Ritika Vankina ◽  
Daniel Wu ◽  
James Yeh ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Immune Thrombocytopenic Purpura ◽  
Case Reports ◽  
Case Vignette ◽  
Mucosal Permeability ◽  
Extraintestinal Manifestation ◽  
Thrombocytopenic Purpura ◽  
Disease Case ◽  
Inflammatory Bowel

While the association of immune thrombocytopenic purpura (ITP) and inflammatory bowel disease (IBD) has been described in a few case reports, management of ITP as an extraintestinal manifestation of Crohn’s disease (CD) is less studied. There are approximately a dozen cases describing the management of patients dually diagnosed with CD/ITP. Previous reports postulated that the mechanism of ITP in CD was through the presence of circulating immune complexes in the serum and antigenic mimicry due to increased mucosal permeability in active colitis, versus increased mucosal production of TH1-type proinflammatory cytokines during CD flares, which may account for remission of ITP with surgery for CD. We present a case of a 27-year-old man who presented with medically refractory CD and ITP who responded to surgical management with colectomy and splenectomy, along with a systematic review of the literature. These cases suggest that colectomy should be considered in the treatment of medically refractory ITP among patients with concomitant CD.

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